Achillea asiatica extract and its active compounds induce cutaneous wound healing

Area of Science:

• Phytochemistry
• Dermatology
• Wound Healing Research

Background:

• Achillea asiatica Serg. is a traditional medicinal herb from the Asteraceae family.
• Historically used for treating inflammation, fever, ulcers, wounds, and rheumatism.

Purpose of the Study:

• To investigate the effects of Achillea asiatica extract (AAE) on cutaneous wound healing.
• To explore the molecular mechanisms underlying AAE's therapeutic potential.

Main Methods:

• Topical application of AAE on incisional wounds in Sprague-Dawley rats.
• In vitro studies using HaCaT keratinocytes, Hs68 dermal fibroblasts, and RAW 264.7 macrophages.
• Assessment of cell viability, migration, nitric oxide (NO), prostaglandin E2 (PGE2), collagen, and inflammatory cytokine expression.

Main Results:

• AAE significantly accelerated wound healing and enhanced epithelialization in rats.
• AAE demonstrated anti-inflammatory properties by reducing NO and PGE2 production.
• AAE promoted collagen synthesis in fibroblasts and keratinocyte differentiation and migration.

Conclusions:

• Achillea asiatica extract (AAE) effectively promotes skin wound healing in rats.
• AAE supports keratinocyte development and exhibits anti-inflammatory and pro-collagen activities.