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Updated: Aug 15, 2026

Isolation, Cryopreservation and Culture of Human Amnion Epithelial Cells for Clinical Applications
Published on: December 21, 2014
A role for amniotic epithelium in control of human parturition
Abstract:
A peroxidase anti-peroxidase staining technique was used to determine the presence of pregnancy-associated prostaglandin synthetase inhibitor (PAPSI) in human amniotic epithelium from 20 pregnant women at 36-40 weeks' gestation. PAPSI was present in amniotic epithelial cells in 12 of 15 women before the onset of labour. No PAPSI was found in amniotic epithelium from 5 women in clinically established labour. These findings indicate that the amnion is a source of this endogenous prostaglandin synthetase inhibitor and suggest a local role for amniotic epithelium in initiating labour at term.
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