Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

4.0K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
4.0K
Neuronal Communication01:28

Neuronal Communication

3.9K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
3.9K
Neuroplasticity01:01

Neuroplasticity

2.1K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.1K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

5.5K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
5.5K
The Blood-brain Barrier00:49

The Blood-brain Barrier

54.1K
Overview
54.1K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.8K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Auditory perceptual maps in humans and mice share common structures and predict perceptual decisions in discrimination learning.

Communications psychology·2026
Same author

Spontaneous and stimulus-driven arousal produce distinct acetylcholine dynamics across sensory and prefrontal cortex.

bioRxiv : the preprint server for biology·2026
Same author

STARR-CRAAVT: A platform to identify cell type-specific regulatory elements for next-generation gene therapy.

iScience·2026
Same author

Representational geometry of sounds in the auditory cortex explains biases in perceptual decision-making in mice.

Cell reports·2026
Same author

Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology.

Communications biology·2025

Related Experiment Video

Updated: Feb 28, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

8.6K

A stable brain from unstable components: Emerging concepts and implications for neural computation.

Anna R Chambers1, Simon Rumpel1

  • 1Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University, Mainz, Germany; Institute of Physiology, Johannes Gutenberg University, Mainz, Germany.

Neuroscience
|June 13, 2017
PubMed
Summary

The adult brain is not a fixed circuit board but a dynamic system. Continuous neural remodeling maintains stable brain functions, offering robustness and flexibility throughout life.

Keywords:
chronic calcium imagingcomputational modelingdendritic spinesneural stabilitysynaptic plasticity

More Related Videos

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.9K
Author Spotlight: Modular Neuronal Networks for Analyzing Brain Functions
07:38

Author Spotlight: Modular Neuronal Networks for Analyzing Brain Functions

Published on: June 7, 2024

2.4K

Related Experiment Videos

Last Updated: Feb 28, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

8.6K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.9K
Author Spotlight: Modular Neuronal Networks for Analyzing Brain Functions
07:38

Author Spotlight: Modular Neuronal Networks for Analyzing Brain Functions

Published on: June 7, 2024

2.4K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Traditional view: adult brain connectivity is fixed like an electronic circuit.
  • Emerging evidence: neural networks remodel dynamically over time, even without learning.
  • Paradox: stable brain functions coexist with constantly changing neural properties.

Purpose of the Study:

  • Reconcile stable brain function with dynamic neural elements.
  • Explore hypotheses for how dynamic circuits maintain stability.
  • Discuss the computational advantages of dynamic neural circuits.

Main Methods:

  • Review of experimental evidence across multiple levels (synapses to neuronal ensembles).
  • Analysis of data from chronic measurements of neural structure and function.
  • Synthesis of theoretical frameworks explaining neural dynamics.

Main Results:

  • Neural parameters exist in a dynamic equilibrium.
  • Continuous neural dynamics are compatible with stable macroscopic behaviors.
  • Dynamic elements offer computational advantages over fixed structures.

Conclusions:

  • Continuous dynamics are a fundamental property of adult neural circuits.
  • This dynamism provides robustness and flexibility.
  • Dynamic neural circuits may possess unique computational abilities.