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Is Multiple Sclerosis Associated With a Lower Intraocular Pressure?

Norah S Lincoff1, Andrea Buccilli, Bianca Weinstock-Guttman

  • 1Department of Neurology and Ophthalmology (NSL), State University of New York at Buffalo School of Medicine, Buffalo, New York; Jacobs MS Center (NSL, BW-G, SG), UBMD Neurology, State University of New York, Buffalo, New York; Ophthalmology Clinic (AB), Lockport, New York; and Ross Eye Institute (SS), University at Buffalo, Buffalo, New York.

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Summary

Multiple sclerosis (MS) is linked to significantly lower intraocular pressure (IOP) compared to individuals without MS. This finding may offer new therapeutic targets for glaucoma treatment.

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Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Intraocular pressure (IOP) is a key factor in glaucoma pathogenesis.
  • The relationship between MS and IOP requires further investigation.

Purpose of the Study:

  • To investigate the association between multiple sclerosis (MS) and intraocular pressure (IOP).
  • To compare IOP levels in patients with MS versus a control group without MS.

Main Methods:

  • Retrospective chart review of 30 patients with clinically definite MS.
  • IOP and central corneal thickness (CCT) measured using kinetic applanation tonometry.
  • Comparison with 30 age-matched controls, with IOP and CCT recorded.

Main Results:

  • The average IOP in the MS group was 12.3 mm Hg, significantly lower than the control group's 17 mm Hg.
  • The presence of MS accounted for 53% of the variability in mean IOP.
  • Analyses were adjusted for age, with 2 subjects excluded due to steroid use.

Conclusions:

  • Intraocular pressure (IOP) is significantly lower in patients with multiple sclerosis (MS) compared to controls.
  • Further prospective studies are needed to explore potential etiologies.
  • Understanding the mechanism of decreased IOP in MS could lead to novel glaucoma therapies.