Related Experiment Video
Updated: Feb 28, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
1.1K
Flavonoids, Thyroid Iodide Uptake and Thyroid Cancer-A Review
Carlos F L Gonçalves1, Mariana L de Freitas2, Andrea C F Ferreira3,4
1Carlos Frederico Lima Gonçalves, Laboratory of Endocrine Physiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil. fredenut@yahoo.com.br.
International Journal of Molecular Sciences
|June 13, 2017
Summary
Flavonoids may improve thyroid cancer treatment by increasing iodide uptake. Some flavonoids, like apigenin and rutin, enhance the sodium-iodide symporter (NIS) function, potentially making radioiodine therapy more effective.
Area of Science:
- Endocrinology
- Oncology
- Pharmacology
Background:
- Thyroid cancer incidence is rising globally.
- Differentiated thyroid carcinomas often rely on radioiodine therapy.
- Loss of sodium-iodide symporter (NIS) function limits radioiodine efficacy.
Purpose of the Study:
- To review the effects of flavonoids on thyroid cancer.
- To examine how flavonoids influence sodium-iodide symporter (NIS) expression and function.
- To explore the potential of flavonoids as adjuvant therapy for thyroid cancer.
Main Methods:
- Literature review of studies on flavonoids, thyroid cancer, and NIS.
- Analysis of data on flavonoid impact on cancer cell proliferation and death.
- Evaluation of evidence for apigenin and rutin in enhancing NIS function in vivo.
Main Results:
- Flavonoids show potential in reducing thyroid cancer cell proliferation and increasing cell death.
- Certain flavonoids can increase NIS mRNA levels and iodide uptake.
- Apigenin and rutin have demonstrated in vivo enhancement of NIS function and expression.
Conclusions:
- Flavonoids may offer a novel therapeutic strategy for thyroid cancer.
- Enhancing NIS function with flavonoids could restore radioiodine sensitivity.
- Flavonoids present a promising avenue for adjuvant therapy in thyroid cancer management.
Related Concept Videos
01:20Synthesis and Regulation of Thyroid Hormones
8.4K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.4K
02:59Cancer Prevention
8.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
8.3K
01:23The Thyroid Gland
8.1K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
8.1K
01:18Functions of Thyroid Hormones
6.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.0K
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
56
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
56