Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

24.4K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.4K
MicroRNAs01:22

MicroRNAs

4.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
Experimental RNAi02:15

Experimental RNAi

8.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
8.1K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
RNA Interference01:23

RNA Interference

28.3K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.3K
RNA Editing02:23

RNA Editing

10.0K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
10.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying nitrogen leaching response to fertilizer additions in China's cropland.

Environmental pollution (Barking, Essex : 1987)·2016
Same author

DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.

International journal of clinical and experimental medicine·2016
Same author

Changes in the metabolome of rats after exposure to arginine and N-carbamylglutamate in combination with diquat, a compound that causes oxidative stress, assessed by 1H NMR spectroscopy.

Food & function·2016
Same author

Morphological Risk Factors for Rupture of Small (<7 mm) Posterior Communicating Artery Aneurysms.

World neurosurgery·2016
Same author

CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages.

Proceedings of the National Academy of Sciences of the United States of America·2015
Same author

The effects of quercetin-loaded PLGA-TPGS nanoparticles on ultraviolet B-induced skin damages in vivo.

Nanomedicine : nanotechnology, biology, and medicine·2015
Same journal

Morphological, molecular, and electrophysiological aspects of skeletal muscle satellite cell-niche interactions: Focus on interstitial stromal non-myogenic cells.

Histology and histopathology·2026
Same journal

Age-related morphological and histological changes in the dromedary camel thymus.

Histology and histopathology·2026
Same journal

Isofraxidin ameliorates CCl<sub>4</sub>-induced liver fibrosis in mice by inhibiting the NF-κB pathway.

Histology and histopathology·2026
Same journal

FOXO3/HMOX1 axis promotes melanoma progression by regulating ferroptosis and immune escape.

Histology and histopathology·2026
Same journal

Immunohistochemical evaluation of CD44 expression and its correlation with clinicopathological factors and molecular markers (EGFR, STAT3, and lipid metabolism-related proteins) in oral squamous cell carcinoma.

Histology and histopathology·2026
Same journal

Betulinic acid mitigates septic cardiomyopathy in mice through modulating the TLR4/MyD88/NF-κB signaling axis and NLRP3 inflammasome pathway.

Histology and histopathology·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

8.1K

MicroRNAs regulate APOBEC gene expression.

Wei Cao1, Wei Wu2,3

  • 1Translational Medical Center, Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China. caoweiyu@hotmail.com.

Histology and Histopathology
|June 13, 2017
PubMed
Summary
This summary is machine-generated.

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) deaminases are crucial for immunity but also drive cancer mutations. Targeting microRNAs could reduce APOBEC-driven mutagenesis and cancer progression.

More Related Videos

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

456
Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
06:58

Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs

Published on: May 18, 2022

1.5K

Related Experiment Videos

Last Updated: Feb 28, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

8.1K
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

456
Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
06:58

Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs

Published on: May 18, 2022

1.5K

Area of Science:

  • Biochemistry
  • Genetics
  • Molecular Biology

Background:

  • APOBEC enzymes are conserved cytidine deaminases with roles in innate immunity.
  • APOBEC3-mediated mutations are prevalent in human cancers.
  • APOBEC3 activation may involve ATR/chk1 pathways.

Purpose of the Study:

  • To review the interaction between microRNAs and the APOBEC gene family.
  • To highlight the post-transcriptional regulation of APOBEC gene expression by microRNAs.
  • To explore the potential of microRNA targeting to reduce APOBEC-driven mutagenesis.

Main Methods:

  • Literature review focusing on microRNA-APOBEC interactions.
  • Analysis of cancer genomics data regarding APOBEC-signature mutations.
  • Discussion of regulatory pathways involving APOBEC3 and ATR/chk1.

Main Results:

  • MicroRNAs post-transcriptionally regulate APOBEC gene expression.
  • APOBEC3-mediated mutations are a significant factor in cancer development.
  • Specific microRNAs influence APOBEC activity.

Conclusions:

  • MicroRNAs play a critical role in modulating APOBEC gene expression.
  • Targeting specific microRNAs offers a potential therapeutic strategy to mitigate APOBEC-driven mutagenesis in cancer.