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Tandem Mass Spectrometry

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Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research

Published on: April 18, 2013

Multianalyte Physiological Microanalytical Devices.

Anna Nix Davis¹, Adam R Travis¹, Dusty R Miller¹

¹Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235;

Annual Review of Analytical Chemistry (Palo Alto, Calif.)

|June 13, 2017

Summary

This summary is machine-generated.

Multianalyte microphysiometers enable real-time electrochemical measurement of metabolites, advancing bioenergetics and neurology research. These devices are key to personalized medicine through automated monitoring and targeted therapies.

Keywords:

biosensor electroanalytical microclinical analyzer multianalyte physiometry multielectrode arrays multiplex

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Published on: June 3, 2015

Area of Science:

Biomedical Engineering
Analytical Chemistry
Physiology

Background:

Scientific instrumentation advances enable novel system evaluations.
Microphysiometers are emerging tools in multianalyte physiometry (MAP).

Purpose of the Study:

To highlight the capabilities of microphysiometers in real-time metabolite analysis.
To discuss the application of MAP in understanding biological responses.
To explore the translational impact of MAP in medicine.

Main Methods:

Electrochemical measurement of metabolite concentration changes.
Simultaneous quantification of multiple analytes in real time.
Development of integrated noninvasive sensor arrays.

Main Results:

Unraveling complex biological pathways in ischemia and oxidative stress.
Contributing to fundamental discoveries in bioenergetics and neurology.
Demonstrating the potential for automated and personalized medical treatments.

Conclusions:

Multianalyte microphysiometers are crucial for advancing biological research.
MAP technologies are paving the way for personalized medicine.
Noninvasive sensor arrays promise continuous monitoring and automated therapeutic delivery.