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Trimester-specific coagulation and anticoagulation reference intervals for healthy pregnancy.
Chanjuan Cui1, Shuo Yang2, Jie Zhang2
1Department of Laboratory Medicine, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Thrombosis Research
|June 13, 2017
Summary
This study establishes trimester-specific reference intervals for coagulation tests and thrombophilia markers in healthy pregnant women of Han ethnicity. These findings aid in accurate diagnosis and management of pregnancy-related hemostatic changes.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Clinical Chemistry
Background:
- Pregnancy significantly alters the hemostatic system due to physiological demands.
- Establishing accurate reference intervals is crucial for monitoring maternal health.
Purpose of the Study:
- To determine trimester-specific reference intervals for coagulation screening tests and thrombophilia markers.
- To provide data for healthy pregnant women of Han ethnicity in North China.
Main Methods:
- Recruited 744 healthy pregnant women and 121 non-pregnant women.
- Analyzed eight hemostasis parameters: APTT, PT, TT, Fib, d-Dimer, AT, PC, and fPS.
- Calculated non-parametric 2.5th-97.5th percentile reference intervals for each trimester.
Main Results:
- Established trimester-specific reference intervals for all eight markers.
- Observed trends: shortened APTT, PT, TT; increased Fib, d-Dimer; decreased AT, PC, fPS from first to third trimester.
- Provided detailed interval ranges for each marker per trimester.
Conclusions:
- Presents the first trimester-specific reference intervals for coagulation and thrombophilia markers in this population.
- Offers essential data for accurate clinical diagnosis and management of hemostatic disorders during pregnancy.
- Highlights the importance of population-specific reference ranges in obstetric care.
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