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Updated: Feb 28, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Isoxazole ring as a useful scaffold in a search for new therapeutic agents
Angelika Sysak1, Bożena Obmińska-Mrukowicz1
1Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, ul. Norwida 31, 50-375 Wrocław, Poland.
Abstract:
Due to its relatively easy synthesis, isoxazole ring has been as an object of interest for chemists and pharmacologists from research groups all over the world. Its chemical modifications include both connection of isoxazole with other aromatic, heteroaromatic or non aromatic rings and substitution with different alkyl groups. Thanks to their usually low cytotoxicity, isoxazole derivatives are still popular scaffolds for the development of new agents with variable biological activities, such as antimicrobial, antiviral, anticancer, anti-inflammatory, immunomodulatory, anticonvulsant or anti-diabetic properties. This review discusses the chemical structure of recently developed isoxazole derivatives with regards to their activity and potential therapeutic use.
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