Related Experiment Video
Updated: Aug 14, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
The role of gamma-glutamyl transpeptidase in alcoholism
Abstract:
The effects of alcohol on the membrane-bound enzyme, gamma-glutamyl transpeptidase, is discussed. Both in vitro and in vivo studies are presented. The chronic administration of alcohol produces an increase of gamma-glutamyl transpeptidase activity in several regions of rat brain whether the alcohol is administered via the inhalational route or by a liquid diet. Rat pups born to mothers which received alcohol throughout gestation are compared to human FAS. In the rat model of FAS the in utero administration of alcohol causes an increase in brain gamma-GTP activity. The use of gamma-GTP as a diagnostic tool in problem drinkers is discussed. A significant positive correlation was found between the amount of alcohol consumed by an individual and serum gamma-GTP activity. Serum from 1 day old pups born to alcoholic mothers and their pair-fed controls were analyzed by gel electrophoresis and stained for gamma-GTP activity. The zymographs of neonatal rats exposed to alcohol in utero were shown to differ from the zymographs of control neonatal rats.
More Related Videos
05:12Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
08:37Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
Published on: November 15, 2024
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
Phase II Reactions: Glucuronidation
Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Hepatic Encephalopathy
Chronic Pancreatitis II: Pathophysiology