Characterization of folic acid-PAMAM conjugates: drug loading efficacy and dendrimer morphology
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Published on: February 9, 2019
P Chanphai1, H A Tajmir-Riahi1
1a Department of Chemistry-Biochemistry and Physics , University of Québec at Trois-Rivières , C. P. 500, Trois-Rivières, Quebec G9A 5H7 , Canada.
Abstract:
We report the loading efficacy of folic acid (FA) by polyamidoamine (PAMAM-G3 and PAMAM-G4) nanoparticles in aqueous solution at physiological pH. Thermodynamic parameters ΔH = -47.57 (kJ Mol-1), ΔS = -122.78 (J Mol-1, K-1) and ΔG = -10.96 (kJ Mol-1) showed FA-PAMAM bindings occur via H-bonding and van der Waals contacts. The stability of acid-PAMAM conjugate increased as polymer size increased. The acid loading efficacy was 40 to 50%. TEM images exhibited major polymer morphological changes upon acid encapsulation. PAMAM dendrimers are capable of FA delivery in vitro.

