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Updated: Feb 28, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
[Changes in electrocardiographic parameters in children with complete left bundle branch block early after
Li Wei1, Yong-Yi Lu, Yi-Min Hua
1Department of Pediatrics, West China Second University Hospital/Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, China. yeqianghua949@sohu.com.
Insights
Electrocardiographic parameters like left ventricular voltage and JTcd differ significantly in children with complete left bundle branch block (CLBBB) after ventricular septal defect (VSD) closure. JTcd may help predict CLBBB development post-VSD intervention.
Area of Science:
- Pediatric Cardiology
- Electrophysiology
- Interventional Cardiology
Background:
- Complete left bundle branch block (CLBBB) can occur after transcatheter closure of ventricular septal defects (VSDs).
- Electrocardiographic (ECG) changes following VSD closure require further investigation, particularly in children with pre-existing CLBBB.
Purpose of the Study:
- To evaluate changes in ECG parameters in pediatric patients with CLBBB after transcatheter VSD closure.
- To compare ECG indices between children with and without CLBBB post-VSD intervention.
Main Methods:
- A cohort of 21 children with CLBBB and 21 matched controls without arrhythmias were studied after perimembranous VSD transcatheter closure.
- ECG parameters including left ventricular voltage, QT interval, and JT dispersion (JTcd) were measured before and at multiple time points after the procedure.
Main Results:
- Left ventricular voltage and JTcd showed significant changes over time in both groups.
- Significant differences in JTcd and left ventricular voltage were observed between the CLBBB and control groups post-procedure.
Conclusions:
- Significant ECG differences, specifically in left ventricular voltage and JTcd, exist between pediatric VSD patients with and without CLBBB early after transcatheter closure.
- JTcd may serve as a potential predictor for the early development of CLBBB following transcatheter VSD closure.
Objective:
To observe the changes in electrocardiographic parameters in children with complete left bundle branch block (CLBBB) after the transcatheter closure of simple ventricular septal defect (VSD).
Methods:
A total of 21 children with CLBBB early after transcatheter closure of perimembranous VSD were recruited. Another 21 children without any type of arrhythmia after transcatheter closure of perimembranous VSD were enrolled as the control group. The sex, age, and the size of occluder were matched between the two groups. The changes in the following indices were compared between the two groups: left ventricular voltage, QT interval, corrected QT interval (QTc), QT dispersion (QTd), corrected QT dispersion (QTcd), JT dispersion (JTd), and corrected JT dispersion (JTcd) on the electrocardiogram before transcatheter closure and at 1, 3, 5, 30 days after transcatheter closure.
Results:
Left ventricular voltage and JTcd changed with operation time in the CLBBB and control groups (P<0.05). There were interaction effects between time and grouping in the changes in left ventricular voltage and QTd (P<0.05). There was a significant difference in JTcd between the CLBBB and control groups (P<0.05). There was also a significant difference in left ventricular voltage between the CLBBB and control groups at 3 and 5 days after the transcatheter closure (P<0.05).
Conclusions:
There are significant differences in electrocardiographic left ventricular voltage and JTcd between VSD children with and without CLBBB early after transcatheter closure. JTcd might be useful in predicting the development of CLBBB early after transcatheter closure of VSD.
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