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Updated: Feb 28, 2026
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
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[Autosomal dominant polycystic kidney disease]
Signe Vinsand Naver1, Bjarne Ørskov, Anja Møller Jensen
1signe.vinsand.naver@regionh.dk.
Ugeskrift for Laeger
|June 14, 2017
Summary
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder causing kidney failure. This review covers ADPKD
Area of Science:
- Nephrology
- Genetics
- Internal Medicine
Background:
- Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disorder.
- It frequently leads to end-stage renal disease.
- Approximately 5,000 individuals in Denmark are affected.
Purpose of the Study:
- To provide a comprehensive overview of ADPKD.
- To discuss clinical presentation, genetics, and pathophysiology.
- To review current and future treatment strategies.
Main Methods:
- Literature review of clinical presentation, genetics, pathophysiology, and treatments for ADPKD.
- Synthesis of information on disease management and therapeutic advancements.
Main Results:
- ADPKD presents with diverse symptoms including hypertension, cyst infections, pain, and abdominal distension due to enlarged kidneys.
- Understanding the genetic basis and disease mechanisms is crucial for management.
- Current treatments focus on symptom management, while future therapies aim to slow disease progression.
Conclusions:
- ADPKD requires ongoing medical management due to its progressive nature.
- Multifaceted approaches combining genetic insights and therapeutic innovations are key.
- Future research holds promise for more effective ADPKD treatments.
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