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Self-assembled supermolecular hydrogel based on hydroxyethyl cellulose: Formation, in vitro release and
Nan Sun1, Ting Wang2, Xiufeng Yan3
1Department of Chemistry, College of Science, Northeast Forestry University, Harbin 150040, PR China.
Carbohydrate Polymers
|June 14, 2017
Summary
A novel cellulose-based hydrogel, gel-(β)CDP-HEC, was developed using host-guest interactions. This supermolecular hydrogel shows efficient encapsulation and bacteriostasis, indicating its potential for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Supramolecular Chemistry
Background:
- Cellulose-based hydrogels are emerging as advanced materials for biomedical uses.
- Supermolecular architectures offer unique properties for drug delivery and tissue engineering.
Purpose of the Study:
- To develop and characterize a novel cellulose-based supermolecular self-assembled hydrogel (gel-(β)CDP-HEC).
- To investigate the hydrogel's encapsulation capacity, drug release profile, thermal stability, and antibacterial properties.
Main Methods:
- Synthesis of hydroxyethyl cellulose grafted with lauryl side chains (HEC-C12) and poly(β-cyclodextrin) (β-CDP).
- Characterization using FTIR, 1H NMR, SEM, GPC, rheology, and swelling ratio analysis.
- Evaluation of phenolphthalein encapsulation, Eugenol loading and release, TGA, and antibacterial activity against Escherichia coli.
Main Results:
- Optimal critical concentrations for HEC-C12 and β-CDP were determined as 30mgmL⁻¹.
- The hydrogel exhibited a high encapsulation capacity of 21.89wt% for phenolphthalein.
- The developed hydrogel demonstrated significant bacteriostasis against Escherichia coli and favorable thermal stability.
Conclusions:
- The novel gel-(β)CDP-HEC hydrogel, formed via host-guest interactions, is a promising supermolecular material.
- Its efficient encapsulation and demonstrated bacteriostasis highlight its potential for advanced biomedical applications, particularly as an antibacterial agent.
