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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.0K

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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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BioInfra.Prot: A comprehensive proteomics workflow including data standardization, protein inference, expression

Michael Turewicz1, Michael Kohl1, Maike Ahrens1

  • 1Medizinisches Proteom-Center, Ruhr-University Bochum, Bochum, Germany.

Journal of Biotechnology
|June 14, 2017
PubMed
Summary

BioInfra.Prot offers a comprehensive proteomics workflow for analyzing high-throughput mass spectrometry data. This service provides state-of-the-art tools for protein identification, quantification, and analysis, ensuring competitive results.

Keywords:
Bioinformatics serviceComputational proteomicsHealth and diseaseMass spectrometryWorkflowde.NBI

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Area of Science:

  • Proteomics
  • Computational Biology
  • Bioinformatics

Background:

  • High-throughput mass spectrometry generates complex proteomics data requiring specialized analysis.
  • Existing workflows may not adequately address the unique challenges of this data type.

Purpose of the Study:

  • To present the de.NBI service center BioInfra.Prot's comprehensive proteomics workflow.
  • To highlight the workflow's components for computational and statistical analysis of proteomics data.

Main Methods:

  • Spectrum identification and protein inference tools.
  • Protein quantification and expression analysis methods.
  • Data standardization and publication utilities.

Main Results:

  • The workflow integrates state-of-the-art and cutting-edge methods.
  • Individual methods provide adequate and competitive results for their specific tasks.
  • Continuous review and updates ensure methods remain current with scientific advancements.

Conclusions:

  • BioInfra.Prot provides a robust and adaptable proteomics analysis workflow.
  • Components are available as standalone services or a complete workflow.
  • Expert support and accessible communication channels facilitate user benefit.