Related Experiment Video
Updated: Feb 28, 2026
08:10
Rescue of Recombinant Zika Virus from a Bacterial Artificial Chromosome cDNA Clone
Published on: June 24, 2019
27.5K
Analysis of synonymous codon usage in Zika virus.
Snawar Hussain1, Sahibzada Tasleem Rasool1
1Department of Biomedical Science, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Acta Tropica
|June 14, 2017
Summary
This study analyzed Zika virus (ZIKV) genomes, finding low codon usage bias. These genetic adaptations influence viral spread and pathogenesis, impacting ZIKV
Area of Science:
- Virology
- Genomics
- Molecular Biology
Background:
- Zika virus (ZIKV) is a zoonotic pathogen that has recently emerged globally.
- Viral adaptation is crucial for replication and persistence in new host species.
- Understanding viral genomic composition and codon usage offers insights into pathogenesis and spread.
Purpose of the Study:
- To investigate the genetic features of the ZIKV genome.
- To analyze the synonymous codon usage bias in ZIKV.
Main Methods:
- Comprehensive analysis of 80 full-length ZIKV sequences.
- Examination of genomic composition and codon usage patterns.
Main Results:
- The overall codon usage bias in the ZIKV genome is low.
- Codon usage bias is influenced by nucleotide composition, protein properties, natural selection, and gene expression levels.
Conclusions:
- The low codon usage bias suggests specific adaptation strategies in ZIKV.
- These findings contribute to understanding ZIKV's pathogenesis and pandemic potential.
Related Concept Videos
02:28Leaky Scanning
5.8K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.8K
01:29Viruses with RNA Genomes
1.1K
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.1K
00:36Viral Mutations
40.1K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
40.1K