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Physical Growth, Morbidity Profile and Mortality Among Healthy Late Preterm Neonates
Priyanka Gupta1, Ritu Mital, Bimlesh Kumar
1Department of Pediatrics, LLRM Medical College, Meerut, UP, India. Correspondence to: Dr Amit Upadhyay, Head, Department of Pediatrics, LLRM Medical College, Meerut, Uttar Pradesh, India. au.llrm@gmail.com.
Insights
Late preterm infants show significantly lower growth and higher illness rates by 12 months compared to term infants. These findings highlight the increased vulnerability of late preterm babies during their first year.
Area of Science:
- Neonatal Health
- Pediatric Growth and Development
- Public Health
Background:
- Late preterm infants (34-36 weeks gestation) represent a significant proportion of births.
- These infants may face unique challenges compared to full-term neonates.
- Understanding their long-term outcomes is crucial for targeted interventions.
Purpose of the Study:
- To compare physical growth, morbidity, and mortality at 12 months between late preterm and term infants.
- To identify specific health risks associated with late preterm birth.
Main Methods:
- A prospective cohort study was conducted in Northern India.
- 200 apparently healthy late preterm and term infants were followed up to 12 months.
- Key outcomes included physical growth parameters, morbidity profile, and mortality.
Main Results:
- Late preterm infants had significantly lower mean weight, length, and head circumference at 12 months (P<0.001).
- Higher odds of being underweight (adjusted OR 4.1), stunted, and wasted were observed in late preterms.
- Increased rates of feeding difficulties, jaundice, re-hospitalization, diarrhea, and fever were noted in the late preterm group.
Conclusions:
- Healthy late preterm infants are at a significantly higher risk of being underweight in the first year of life.
- Late preterm birth is associated with increased morbidity during infancy.
- These findings underscore the need for continued monitoring and support for late preterm infants.
Objective:
To compare the physical growth outcomes, morbidity profile and mortality at an age of 12 months among late preterm (34 0/7to 36 6/7) neonates to term (37 0/7to 41 6/7) neonates.
Study Design:
Prospective cohort study.
Setting:
A tertiary care center of Northern India during 2014-2015.
Participants:
200 apparently healthy late preterms and term infants, followed up to 12 months of age.
Main Outcome Measures:
Physical growth parameters, morbidity profile and mortality.
Results:
At mean age of 12 months, mean (SD) weight, length and head circumference of late preterms were 7.4 (0.8) kg, 69.2 (2.5) cm and 43.0 (1.1) cm, respectively; which were significantly lower than that of the full term infants [8.7 (1.6) kg, 72.2 (3.1) cm and 44.2 (1.1) cm] (P< 0.001). On univariate analysis, late preterm group was associated with higher odds (95% CI) of being underweight [5.6 (3.4, 5.5)], stunted [3.5 (2.1, 5.8)] and wasted [3.6 (1.9, 6.9)]. On multivariate analysis, only adjusted odds of late preterms becoming underweight by one year was significant [OR 4.1; 95% CI (1.6, 10.4)]. Feeding difficulties, jaundice and re-hospitalization rates were significantly higher in the late preterm group. The median (IQR) episodes per baby for late preterms as compared to terms for diarrhea [1.84 (0,3) vs 1.14 (0,2) (P <0.001)], and fever [1.33 (0,2) vs. 0.95 (0,2) (P = 0.01)] were higher.
Conclusion:
Healthy late preterms are at significantly higher risk of being underweight in the first year of life, in addition to having significantly higher morbidity.
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