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Updated: Feb 28, 2026

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Histologic Sequelae of Apical Hypertrophic Cardiomyopathy: Dystrophic Calcification

Shahryar G Saba1,2, John N Makaryus1, Navid Rahmani2

  • 1Multimodality Cardiovascular Imaging Laboratory, Department of Cardiology, Hofstra Northwell School of Medicine, Manhasset, NY, USA.

Clinical Medicine Insights. Cardiology
|June 14, 2017
PubMed

Insights

Cardiac computed tomography (CT) reveals apical hypertrophic cardiomyopathy with calcification. This suggests chronic injury, not atherosclerotic coronary artery disease, causes apical dysfunction, highlighting CT

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiovascular Disease

Background:

  • Apical hypertrophic cardiomyopathy is a form of heart muscle disease.
  • Dystrophic calcification can occur in injured myocardial tissue.
  • Distinguishing causes of apical myocardial dysfunction is clinically important.

Purpose of the Study:

  • To present cardiac computed tomography (CT) findings in apical hypertrophic cardiomyopathy.
  • To investigate the etiology of apical myocardial dysfunction in this condition.
  • To evaluate the role of CT in visualizing myocardial calcification.

Main Methods:

  • Cardiac computed tomography (CT) was used to assess left ventricular apex morphology.
  • Coronary CT angiography was performed to evaluate epicardial coronary arteries.
  • Analysis focused on identifying hypertrophic cardiomyopathy, calcification, and coronary artery disease.

Main Results:

  • Cardiac CT demonstrated apical hypertrophic cardiomyopathy with dystrophic calcification of the left ventricular apex.
  • Coronary CT angiography showed no significant epicardial coronary artery disease.
  • Findings suggest increased wall tension and reduced microvascular perfusion contribute to apical dysfunction.

Conclusions:

  • Cardiac CT is valuable for diagnosing apical hypertrophic cardiomyopathy and associated calcification.
  • The findings support non-atherosclerotic mechanisms for apical myocardial injury.
  • CT imaging is effective for visualizing calcium deposition in chronically injured myocardium.

Keywords:
Hypertrophic cardiomyopathymultidetector cardiac CTmyocardial calcification

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