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Related Experiment Video

Updated: Feb 28, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Relationship between timed 25-foot walk and diffusion tensor imaging in multiple sclerosis.

Sylvia Klineova1, Rebecca Farber1, Catarina Saiote2

  • 1The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Icahn School of Medicine at Mount Sinai, USA.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
|June 14, 2017
PubMed
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Diffusion tensor imaging (DTI) metrics show promise as objective markers for multiple sclerosis (MS) gait impairment. Brain mean diffusivity in corticospinal tracts strongly correlates with walking ability, offering a potential tool for assessing disability.

Area of Science:

  • Neuroimaging
  • Neurology
  • Biomarkers

Background:

  • Gait impairment significantly affects the quality of life for most multiple sclerosis (MS) patients.
  • The timed 25-foot walk is a common but variable measure of gait disability.
  • Objective biological markers are needed to accurately assess MS-related walking difficulties.

Purpose of the Study:

  • To investigate the relationship between gait impairment in MS patients and imaging markers.
  • To explore the utility of diffusion tensor imaging (DTI) in quantifying neurological changes related to walking ability.

Main Methods:

  • A cohort of MS patients with gait impairment underwent MRI scans of the brain and cervical spinal cord.
  • Diffusion tensor imaging (DTI) metrics, including mean diffusivity and fractional anisotropy, were measured in the brain's corticospinal tracts and the spinal cord at C2/3.
Keywords:
Multiple sclerosisbiological markerdiffusion tensor imaginggait

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  • Relationships between baseline timed 25-foot walk performance and various MRI/DTI markers were analyzed.

    • Main Results:

    • Multivariate linear regression revealed significant associations between DTI metrics and gait impairment.
    • Brain mean diffusivity in corticospinal tracts was a strong predictor of timed 25-foot walk performance (p=0.004).
    • Other significant markers included brain corticospinal tracts axial/radial diffusivity, grey matter volume, white matter volume, and normalized brain volume.

    Conclusions:

    • Diffusion tensor imaging (DTI) metrics, particularly mean diffusivity in the brain's corticospinal tracts, are associated with gait impairment in multiple sclerosis (MS).
    • These findings suggest DTI can serve as an objective biomarker for assessing walking ability in MS patients.