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Biomarkers of Renal Function: Towards Clinical Actionability
S Heleen Binnenmars1, R S Hijmans1, G Navis1
1University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Clinical Pharmacology and Therapeutics
|June 14, 2017
Summary
This review explores the clinical value of renal biomarkers for acute kidney injury and chronic kidney disease. Metabolic biomarkers are highlighted as highly actionable, offering improved treatment responses and outcomes.
Area of Science:
- Nephrology
- Clinical Chemistry
- Biomarker Discovery
Background:
- Renal biomarkers are crucial for diagnosing and managing kidney diseases.
- Current biomarkers for acute kidney injury (AKI) and chronic kidney disease (CKD) have varying clinical utility.
- Actionability, defined by treatment response and outcomes, is a key metric for biomarker evaluation.
Purpose of the Study:
- To review the clinical value of key renal biomarkers for AKI and CKD.
- To categorize biomarkers based on their actionability.
- To introduce and emphasize the potential of metabolic biomarkers.
Main Methods:
- Literature review of clinical studies on renal biomarkers.
- Categorization of biomarkers by documented treatment response and outcomes.
- Identification and description of a novel category: metabolic biomarkers.
Main Results:
- Established renal biomarkers for AKI and CKD were assessed for clinical utility.
- Biomarkers were classified according to their actionability in patient management.
- Metabolic biomarkers emerged as a promising, highly actionable category.
Conclusions:
- The actionability of renal biomarkers significantly impacts clinical decision-making.
- Metabolic biomarkers represent a valuable advancement in assessing and treating kidney conditions.
- Further research into metabolic biomarkers is warranted to optimize patient care in AKI and CKD.
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