Fluorine-18 labelled building blocks for PET tracer synthesis

Area of Science:

• Radiochemistry and Nuclear Medicine

Background:

• Positron Emission Tomography (PET) is crucial in modern healthcare.
• Fluorine-18 is the most common radioisotope for PET imaging.
• Developing new PET tracers requires understanding radiochemistry methodologies.

Purpose of the Study:

• To provide a comprehensive overview of fluorine-18 labeled building blocks.
• To review their synthesis and applications since 2010.
• To guide the selection of synthetic approaches for novel PET tracers.

Main Methods:

• Review of literature on fluorine-18 labeled building blocks.
• Analysis of synthetic strategies including late-stage radiofluorination and building block approaches.
• Examination of applications of these building blocks in PET tracer development.

Main Results:

• Significant advancements in the synthesis of fluorine-18 labeled building blocks since 2010.
• Demonstration of the efficiency of the building block approach for PET tracer synthesis.
• Diverse applications of these building blocks across various research areas.

Conclusions:

• Fluorine-18 labeled building blocks are essential tools for PET tracer development.
• The building block approach offers a versatile and efficient strategy for synthesizing PET tracers.
• Continued research in this area will drive innovation in PET imaging and diagnostics.