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HIV in the dialysis population: Current issues and future directions
Suzanne M Boyle1, Dong H Lee2, Christina M Wyatt3
1Division of Nephrology and Hypertension, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
Seminars in Dialysis
|June 14, 2017
Summary
Antiretroviral therapy improves survival for HIV patients, but aging individuals face more kidney disease. Advances in HIV treatment and kidney transplants offer new care options for these patients.
Area of Science:
- Nephrology
- Infectious Diseases
- Gerontology
Background:
- Antiretroviral therapy (ART) has transformed HIV management, reducing mortality.
- An aging HIV-positive population experiences increased comorbidity, particularly chronic kidney disease (CKD).
- End-stage renal disease (ESRD) presents a growing challenge in HIV-infected individuals.
Purpose of the Study:
- To review the evolving epidemiology of CKD and ESRD in the aging HIV population.
- To highlight advancements in ART impacting kidney health.
- To discuss the role of kidney transplantation in HIV-positive ESRD patients.
Main Methods:
- Literature review of epidemiological trends in HIV and kidney disease.
- Analysis of recent developments in antiretroviral drug regimens.
- Examination of outcomes for kidney transplantation in HIV-positive recipients.
Main Results:
- HIV-infected individuals are experiencing higher rates of CKD and ESRD.
- Novel ART regimens may offer improved renal safety profiles.
- Successful kidney transplantation is increasingly feasible for select HIV-positive patients.
Conclusions:
- Managing kidney disease is crucial for the aging HIV population.
- Optimized ART and transplantation are key strategies for improving outcomes.
- Multidisciplinary care is essential for HIV patients with ESRD.
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