Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Data Validation01:03

Data Validation

7.1K
Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...
7.1K
Data Validation01:15

Data Validation

3.3K
Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
3.3K
Reliability and Validity01:29

Reliability and Validity

14.2K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
14.2K
Revisionist Views of Adolescent and Adult Cognition01:24

Revisionist Views of Adolescent and Adult Cognition

351
A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
351
Naturalistic Observations02:30

Naturalistic Observations

17.9K
If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
17.9K
Development of Analytical Methods01:21

Development of Analytical Methods

2.8K
An analytical methodology can be divided into four sequential steps: technique, method, procedure, and protocol. A technique is a scientific principle that rationalizes a specific phenomenon through chemical measurements. Adapting a technique for analyzing a sample of interest is termed a method. The procedure outlines the directions for performing the analysis via an analytical method. The protocol is the detailed guidelines on the procedure, which should be strictly followed to obtain the...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Keratin 17 immunocytochemistry in urine cytology for urothelial carcinoma detection: Diagnostic performance and interobserver agreement in a prospective real-world cohort.

Cancer cytopathology·2026
Same journal

New progress in addressing cancer pain: Recent studies have offered revealing insights into predisposing, precipitating, and perpetuating factors as well as underlying mechanisms and potential interventions.

Cancer cytopathology·2026
Same journal

Molecular profiling of breast cancer pleural effusions using cytology specimens: Impact of sample source and cytological features on next-generation sequencing performance.

Cancer cytopathology·2026
Same journal

Accurate focal-plane selection is crucial for artificial intelligence assessment of three-dimensional urine cytology specimens for bladder cancer screening and surveillance.

Cancer cytopathology·2026
Same journal

Application of the International System for Serous Fluid Cytopathology in cerebrospinal fluid cytology: Overall survival analysis associated with diagnostic categories.

Cancer cytopathology·2026
Same journal

The performance of intraoperative peritoneal washings in detecting pancreatic ductal adenocarcinoma.

Cancer cytopathology·2026

Related Experiment Video

Updated: Feb 28, 2026

Qualitative and Quantitative Validation of Tools with Rating Scales Aimed at Assessing the Quality of University Service-Learning
10:39

Qualitative and Quantitative Validation of Tools with Rating Scales Aimed at Assessing the Quality of University Service-Learning

Published on: August 29, 2025

1.3K

Analytic inquiry: Validation and practical considerations.

Anna B Berry1

  • 1CellNetix Pathology and Laboratories LLC, Seattle, Washington.

Cancer Cytopathology
|June 14, 2017
PubMed
Summary
This summary is machine-generated.

This review guides cytopathology labs in validating molecular tests, addressing challenges like inexperience and regulatory hurdles. It covers practical aspects for integrating molecular diagnostics and next-generation sequencing into cytopathology services.

Keywords:
cytopathologymolecular diagnosticsnext-generation sequencingvalidation

More Related Videos

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

4.7K
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.3K

Related Experiment Videos

Last Updated: Feb 28, 2026

Qualitative and Quantitative Validation of Tools with Rating Scales Aimed at Assessing the Quality of University Service-Learning
10:39

Qualitative and Quantitative Validation of Tools with Rating Scales Aimed at Assessing the Quality of University Service-Learning

Published on: August 29, 2025

1.3K
Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

4.7K
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.3K

Area of Science:

  • Medical Diagnostics
  • Molecular Biology
  • Cytopathology

Background:

  • Molecular diagnostics and cytopathology are complementary services that enhance patient care.
  • Cytopathology laboratories often hesitate to adopt molecular tests due to validation inexperience.
  • Integrating molecular testing requires understanding specific challenges.

Purpose of the Study:

  • To provide a guide for validating molecular tests in cytopathology.
  • To address regulatory constraints and practical considerations for molecular test validation.
  • To discuss issues specific to cytopathology samples and next-generation sequencing.

Main Methods:

  • Review of basic principles of molecular test validation.
  • Discussion of regulatory and practical considerations.
  • Examination of issues unique to cytopathology samples and next-generation sequencing.

Main Results:

  • Validation of molecular tests is crucial for optimal patient care.
  • Inexperience is a barrier to molecular test adoption in cytopathology.
  • Specific guidance is needed for validating molecular tests in this setting.

Conclusions:

  • Molecular test validation is essential for cytopathology laboratories.
  • Addressing validation challenges facilitates the integration of molecular diagnostics.
  • This review serves as a general guide for cytopathology labs.