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Updated: Feb 28, 2026

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

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Emerging β-Sheet Rich Conformations in Supercompact Huntingtin Exon-1 Mutant Structures

Hongsuk Kang1, Francisco X Vázquez1, Leili Zhang1

  • 1Computational Biology Center, IBM Thomas J. Watson Research Center , Yorktown Heights, New York 10598, United States.

Journal of the American Chemical Society
|June 14, 2017
PubMed
Summary

Huntington's disease (HD) is linked to polyglutamine (polyQ) in Huntingtin protein (Htt). Molecular dynamics simulations reveal longer polyQ tracts form supercompact structures due to glutamine side chain interactions, explaining HD pathogenesis.

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