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Association of asthma with coronary heart disease: A meta analysis of 11 trials

Lida Wang1, Shuyan Gao2, Mingdong Yu3

  • 1Department of E.N.T, Weifang People's Hospital, Weifang, China.

Plos One
|June 14, 2017
PubMed

Insights

Asthma is linked to increased coronary heart disease (CHD) risk, particularly in females with adult-onset asthma. Further research is needed to confirm these findings on asthma and heart disease.

Area of Science:

  • Cardiology
  • Pulmonology
  • Epidemiology

Background:

  • The association between asthma and coronary heart disease (CHD) lacks consistent description.
  • Understanding gender and asthma onset influences on this relationship is crucial.

Purpose of the Study:

  • To define the relationship between asthma and CHD.
  • To explore the impact of gender and asthma onset (child- vs. adult-onset) on this association.

Main Methods:

  • Systematic review of published reports on asthma and CHD.
  • Meta-analysis of eleven identified trials involving 666,355 subjects.

Main Results:

  • Asthma overall showed a significant association with CHD in both prospective and retrospective studies.
  • Females with asthma had a significantly higher risk of CHD, while males did not show a significant association.
  • Only females with adult-onset asthma demonstrated a significant association with increased CHD risk.

Conclusions:

  • Asthma is associated with CHD, primarily driven by females with adult-onset asthma.
  • These findings suggest a specific risk profile for certain asthma populations.
  • Study limitations necessitate cautious interpretation of the results.
Abstract

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