Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical course and prognostic disparities of pyoderma gangrenosum based on underlying disease: A long-term comparative study in 124 patients.

Annales de dermatologie et de venereologie·2025

Same author

Exploring Remission Dynamics and Prognostic Factors in Lichen Planopilaris: A Retrospective Cohort Study.

Dermatology (Basel, Switzerland)·2024

Same author

Improved effectiveness of an increased dose of griseofulvin for treating Tinea capitis among refugee children in Israel: A retrospective cohort study.

Mycoses·2023

Same author

Percutaneous ethanol sclerotherapy is a promising treatment for recalcitrant angiolymphoid hyperplasia with eosinophilia.

Clinical and experimental dermatology·2021

Same author

Agminated benign vascular tumour successfully treated with trametinib.

The British journal of dermatology·2021

Same author

Interleukin-17 is a potential player and treatment target in severe chronic spontaneous urticaria.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2020

Search research articles

Related Experiment Video

Updated: Feb 28, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Psoriasis comorbidity affects multiple sclerosis neurological progression: a retrospective case - control analysis.

G Miron^1,2, M Gurevich¹, S Baum³

¹Multiple Sclerosis Center, Sheba Medical Center, Ramat Gan, Israel.

Journal of the European Academy of Dermatology and Venereology : JEADV

|June 14, 2017

Summary

Psoriasis comorbidity in multiple sclerosis (MS) patients may indicate a slower disease progression. This finding suggests a potential link between these inflammatory conditions and MS disability.

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Related Experiment Videos

Last Updated: Feb 28, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Area of Science:

Immunodermatology
Neuroimmunology

Background:

Multiple sclerosis (MS) and psoriasis are chronic inflammatory conditions with known epidemiological and biological links.
The impact of comorbid psoriasis on the clinical course of multiple sclerosis has not been previously investigated.

Purpose of the Study:

To characterize patients with both psoriasis and MS.
To determine if the presence of psoriasis influences the progression of multiple sclerosis.

Main Methods:

Retrospective case-control study utilizing data from the Sheba Hospital Multiple Sclerosis Center database.
Identified MS patients with psoriasis comorbidity and compared their clinical and demographic characteristics to a matched cohort of MS-only patients.
Analyzed MS progression outcomes in patients with over 5 years of follow-up.

Main Results:

1.3% of MS patients (45/3456) had comorbid psoriasis, with psoriasis preceding MS in 78% of cases.
Patients with psoriasis onset before relapsing-remitting MS (RRMS) exhibited slower disease progression.
This slower progression was evidenced by a significantly longer time to a second relapse (P < 0.01) and to significant neurological disability (P < 0.03).

Conclusions:

Psoriasis comorbidity, particularly when preceding MS onset, is associated with a slower rate of disability progression in multiple sclerosis patients.
This suggests a potential modifying effect of psoriasis on MS pathogenesis or clinical trajectory.