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Psoriasis comorbidity affects multiple sclerosis neurological progression: a retrospective case - control analysis

G Miron1,2, M Gurevich1, S Baum3

  • 1Multiple Sclerosis Center, Sheba Medical Center, Ramat Gan, Israel.

Journal of the European Academy of Dermatology and Venereology : JEADV
|June 14, 2017
PubMed
Abstract

Insights

Psoriasis comorbidity in multiple sclerosis (MS) patients may indicate a slower disease progression. This finding suggests a potential link between these inflammatory conditions and MS disability.

Area of Science:

  • Immunodermatology
  • Neuroimmunology

Background:

  • Multiple sclerosis (MS) and psoriasis are chronic inflammatory conditions with known epidemiological and biological links.
  • The impact of comorbid psoriasis on the clinical course of multiple sclerosis has not been previously investigated.

Purpose of the Study:

  • To characterize patients with both psoriasis and MS.
  • To determine if the presence of psoriasis influences the progression of multiple sclerosis.

Main Methods:

  • Retrospective case-control study utilizing data from the Sheba Hospital Multiple Sclerosis Center database.
  • Identified MS patients with psoriasis comorbidity and compared their clinical and demographic characteristics to a matched cohort of MS-only patients.
  • Analyzed MS progression outcomes in patients with over 5 years of follow-up.

Main Results:

  • 1.3% of MS patients (45/3456) had comorbid psoriasis, with psoriasis preceding MS in 78% of cases.
  • Patients with psoriasis onset before relapsing-remitting MS (RRMS) exhibited slower disease progression.
  • This slower progression was evidenced by a significantly longer time to a second relapse (P < 0.01) and to significant neurological disability (P < 0.03).

Conclusions:

  • Psoriasis comorbidity, particularly when preceding MS onset, is associated with a slower rate of disability progression in multiple sclerosis patients.
  • This suggests a potential modifying effect of psoriasis on MS pathogenesis or clinical trajectory.

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