Effect of dimethyl sulfoxide on dentin collagen

Area of Science:

• Biomaterials Science
• Dental Materials
• Surface Chemistry

Background:

• Adhesive infiltration into dentin is crucial for dental restorations.
• Dentin wettability, influenced by surface energy, affects adhesive interaction.
• Dimethyl sulfoxide (DMSO) is explored for its potential to modify dentin surface properties.

Purpose of the Study:

• To investigate the impact of dimethyl sulfoxide (DMSO) on demineralized dentin wettability.
• To assess the effect of DMSO on dentin organic matrix expansion and shrinkage.
• To correlate DMSO concentration with changes in surface tension and dentin properties.

Main Methods:

• Sessile drop contact angle measurements were used to evaluate dentin wettability on demineralized dentin treated with 1-5% DMSO.
• Linear variable differential transformer (LVDT) measured dentinal matrix expansion/shrinkage.
• Surface tension of DMSO-water mixtures was analyzed across various concentrations.

Main Results:

• 1-5% DMSO pretreatment significantly increased dentin wettability in a concentration-dependent manner.
• Demineralized dentin samples showed less expansion with DMSO-water mixtures compared to pure water, except at high DMSO concentrations (≥80%).
• Drying times of samples increased significantly when using DMSO.

Conclusions:

• Increased dentin wettability by DMSO can enhance adhesive penetration.
• DMSO-induced collagen matrix expansion may contribute to improved dentin adhesive bonding.
• DMSO shows potential as a pretreatment agent to optimize dentin surface for adhesive procedures.