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Related Experiment Video

Updated: Feb 28, 2026

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Mechanisms of Connectome Development.

Marcus Kaiser1

  • 1ICOS Research Group, School of Computing Science, Newcastle University, Newcastle upon Tyne, UK; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

Trends in Cognitive Sciences
|June 15, 2017
PubMed
Summary

This study explores principles of brain network development, linking spatial and temporal factors to health and disease. Understanding these developmental origins is key for personalized brain disease treatments.

Keywords:
Caenorhabditis elegansbrain connectivitycortical biological networkshumanmacaqueneural networksneuronal networksrodent

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Computational Biology

Background:

  • D'Arcy Thompson's 'On Growth and Form' laid groundwork for understanding morphological changes.
  • Recent advances enable studying anatomical brain network changes.
  • Connectome development principles are being elucidated.

Purpose of the Study:

  • Outline principles for connectome development.
  • Describe how spatial and temporal factors shape brain network development in health and disease.
  • Highlight the importance of understanding developmental origins for personalized medicine.

Main Methods:

  • Review of recent experimental advances in studying anatomical brain networks.
  • Analysis of spatial and temporal factors influencing connectome development.
  • Discussion of the role of computational models and longitudinal studies.

Main Results:

  • Spatial and temporal factors significantly shape brain network development.
  • Understanding developmental trajectories is crucial for diagnosing and treating brain diseases.
  • Connectome development principles are emerging from experimental and theoretical work.

Conclusions:

  • Longitudinal studies are essential for understanding brain network development.
  • Experimentally derived parameters for connection formation are needed.
  • Biologically realistic computational models are vital for linking brain network development, structure, and function.