CD155 blockade improves survival in experimental sepsis by reversing dendritic cell dysfunction

Immunosuppression is involved in septic processes, and results in an inability to eradicate the primary infection as well as a propensity to acquire secondary infections. In the present study, we found that the expression of CD155 on dendritic cells (DCs) and TIGIT on T cells were strikingly increased in septic mice. Furthermore, anti-CD155 antibody treatment could improve survival rate in mouse sepsis models through deceasing bacterial burden in both blood and peritoneal lavage fluid. Meanwhile, CD155 blockade efficiently increased the expression of TNF-a, IL-6 and decreased the level of IL-10 in blood and peritoneal lavage fluid of septic mice. In addition, overexpression of CD155 did not affect DCs maturation marker genes, but significantly increased the production of IL-10 and reduced the production of IL-12p40 and IL-12p70. Consequently, our data suggest that increase of CD155 on DCs promotes immunosuppressive effects by modulating cytokine production in sepsis.