[The preparation and histaminergic properties of 2-(2-oxo-4-imidazolin-4-yl)ethylamine]

Carrying on the study of the effects induced by substitution at position 2- of histamine imidazole ring, this article briefly reports the synthesis of 2-(2-oxo-4-imidazolin-4-yl)ethylamine. The pharmacological properties of this compound and its sulphurated analogue 2-(2-thiono-4-imidazolin-4-yl)ethylamine, showed that the marked structural modification of the critical moieties involved in the binding at the H1- and H2-receptors resulted in a loss of histamine-like activity.