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Independent Predictors of Mortality and Resource Utilization in Viral Hepatitis Related Hepatocellular Carcinoma

Pegah Golabi1, Thomas Jeffers1, Zahra Younoszai1

  • 1Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States.

Annals of Hepatology
|June 15, 2017
PubMed

Insights

Hepatitis B (HBV) and C (HCV) viral infections significantly increase hepatocellular carcinoma (HCC) risk. Patients with HBV- or HCV-related HCC face higher mortality and healthcare costs compared to controls.

Area of Science:

  • Hepatology
  • Oncology
  • Public Health

Background:

  • Hepatitis B (HBV) and Hepatitis C (HCV) are leading causes of liver cancer.
  • Understanding the impact of viral hepatitis on hepatocellular carcinoma (HCC) is crucial for public health strategies.

Purpose of the Study:

  • To evaluate mortality rates and healthcare resource utilization in patients with HBV- and HCV-related HCC.
  • To identify risk factors associated with increased mortality in HCC patients with viral hepatitis.

Main Methods:

  • Utilized the SEER-Medicare linked database (2001-2009).
  • Included 2,711 HCC cases (HBV/HCV-related) and 5,130 non-cancer controls (HBV/HCV).
  • Employed t-tests, chi-square tests, and logistic regression for comparative and multivariate analyses.

Main Results:

  • The incidence of viral hepatitis-related HCC increased between 2001-2009.
  • HCC patients with HBV/HCV were older, more male, had higher rates of decompensated cirrhosis, and experienced significantly greater one-year mortality (49.3% HBV, 52.2% HCV) compared to controls (20.3% HBV, 19.2% HCV).
  • Higher inpatient and outpatient healthcare charges were observed in HBV/HCV-related HCC patients.

Conclusions:

  • Viral hepatitis-related HCC is an increasing public health concern.
  • Mortality and substantial healthcare resource utilization are associated with HBV- and HCV-related HCC.
  • Older age, male sex, and decompensated cirrhosis are independent predictors of one-year mortality in this population.
Abstract

Keywords:
HBVHCV.HCC. Death. Cost effectiveness.

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