Related Experiment Video
Updated: Feb 28, 2026
06:15
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
1.9K
Perianal Pagetoid Intraepithelial Carcinoma
Suanga Sisodia1, Robin Boushey2, Goo Lee3
1aDivision of Radiation Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, Ontario, Canada.
Case Reports in Gastroenterology
|June 15, 2017
Summary
Extramammary Paget disease (EMPD) of the perianal region is rare. This case highlights aggressive surgical management for perianal pagetoid intraepithelial carcinoma, emphasizing the need for improved risk stratification in managing this challenging condition.
Area of Science:
- Oncology
- Dermatology
- Gastroenterology
Background:
- Extramammary Paget disease (EMPD) in the perianal region is uncommon and difficult to treat.
- Primary EMPD presents as noninvasive epidermal lesions, while secondary EMPD arises from underlying malignancies.
- Distinguishing between primary and secondary EMPD can be challenging without detected malignancies.
Observation:
- A 74-year-old woman presented with perianal pagetoid intraepithelial carcinoma.
- Initial workup did not reveal an obvious underlying malignancy.
- The patient opted for aggressive surgical management.
Findings:
- The case underscores the rarity and complexity of managing perianal EMPD.
- Aggressive surgical intervention was chosen despite the absence of a detected primary tumor.
- Continued case reporting is crucial for improving risk stratification and treatment strategies.
Implications:
- Further research and case studies are needed to refine diagnostic criteria for perianal EMPD.
- Optimal management strategies for perianal EMPD, especially with suspected occult cancers, require further elucidation.
- Early and aggressive management may be warranted in select cases of perianal EMPD to improve patient outcomes.
Related Concept Videos
01:25Assessment of the Rectum and Anus
1.5K
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
1.5K
01:21Inflammatory Bowel Disease V: Surgical Management
780
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
780
01:11Papillary Dermis
6.3K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.3K
01:35Cancer Cell Migration through Invadopodia
3.4K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.4K
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.4K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.4K
01:23Renewal of Intestinal Stem Cells
3.4K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.4K