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Antigen challenge and canine tracheal mucus
International Archives of Allergy and Applied Immunology
|January 1, 1985
Summary
Ascaris suum antigen inhalation causes tracheal mucus hypersecretion in sensitive dogs, affecting mucus properties. This response involves histamine release and cholinergic mechanisms, similar to methacholine and histamine.
Area of Science:
- Immunology
- Respiratory Physiology
- Pharmacology
Background:
- Cutaneous sensitivity to Ascaris suum antigen is common in dogs.
- Tracheal mucus hypersecretion plays a role in respiratory defense but can be detrimental when excessive.
Purpose of the Study:
- To investigate the mechanisms of tracheal mucus hypersecretion induced by Ascaris suum antigen challenge in dogs.
- To explore the relationship between antigen sensitivity and the dose-response of mucus hypersecretion.
Main Methods:
- Dogs with known cutaneous sensitivity to Ascaris suum were challenged with antigen aerosols.
- Mucus hypersecretion and viscoelasticity were measured.
- The effects of atropine, H1-antagonists, and thiazinamium chloride on antigen-induced responses were evaluated.
Main Results:
- Ascaris suum antigen aerosol challenge induced tracheal mucus hypersecretion and altered mucus viscoelasticity in sensitive dogs.
- A correlation was observed between skin sensitivity and the threshold aerosol dose for hypersecretion.
- Pretreatment with atropine, H1-antagonists, and thiazinamium chloride significantly reduced the antigen-induced hypersecretion.
Conclusions:
- Tracheal mucus hypersecretion in response to Ascaris suum challenge involves histamine release.
- Cholinergic mechanisms contribute to the antigen-induced mucus hypersecretion.
- The findings suggest a dual mechanism involving histamine and cholinergic pathways in this model of airway hyperresponsiveness.