Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

10.5K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
10.5K
Development of Immunocompetence01:22

Development of Immunocompetence

1.0K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.0K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

10.1K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
10.1K
What is the Immune System?01:38

What is the Immune System?

137.6K
Overview
137.6K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.2K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.2K
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

18.4K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
18.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence that injury can cause <i>Drosophila</i> gut differentiated, polyploid enterocytes to be recruited as stem cells via paligenosis.

bioRxiv : the preprint server for biology·2026
Same author

Growing Up with Breastfeeding.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2025
Same author

Preterm Neonates with Umbilical Venous Catheter and Radiographic Abnormalities Overlying the Liver.

NeoReviews·2024
Same author

ABM Clinical Protocol #35: Supporting Breastfeeding During Maternal or Child Hospitalization.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2021
Same author

Increasing awareness and uptake of the MenB vaccine on a large university campus.

Human vaccines & immunotherapeutics·2021
Same author

Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects?

Alzheimer's research & therapy·2021

Related Experiment Video

Updated: Feb 28, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

4.2K

Innate Immunity and Breast Milk.

Nicole Theresa Cacho1, Robert M Lawrence2

  • 1Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL, United States.

Frontiers in Immunology
|June 15, 2017
PubMed
Summary

Human milk provides crucial innate immunity for infants through bioactive components and its microbiome. Research reveals its dynamic role in immune protection, gut health, and potential for stem cell applications.

Keywords:
breast milkcolostrumhuman milkinnate immunitypreterm

More Related Videos

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
08:12

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

7.7K
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

20.0K

Related Experiment Videos

Last Updated: Feb 28, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

4.2K
Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
08:12

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

7.7K
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

20.0K

Area of Science:

  • Immunology
  • Microbiology
  • Developmental Biology

Background:

  • Infants possess immature immune systems, increasing infection risk.
  • Human milk is vital for infant growth, development, and immune system maturation.
  • Understanding human milk's role in innate immunity is crucial for infant health.

Purpose of the Study:

  • To review the direct contributions of human milk to infant innate immunity.
  • To highlight novel findings on human milk's bioactive components and their functions.
  • To explore the impact of human milk on the infant's gut microbiome and immune development.

Main Methods:

  • Review of current scientific literature and research findings.
  • Application of advanced techniques like genomics, metabolomics, proteomics, and glycomics.
  • Analysis of antimicrobial proteins, anti-inflammatory factors, and stem cells in human milk.

Main Results:

  • Human milk bioactive components offer multifaceted immune protection and reduce inflammation.
  • The human milk microbiome and oligosaccharides shape the infant's gut microbiome.
  • Antimicrobial proteins/peptides and anti-inflammatory factors enhance innate immunity.
  • Human milk contains stem cells (hMSCs) with potential for infant repair and regeneration.

Conclusions:

  • Human milk plays a significant role in establishing infant innate immunity and gut health.
  • Ongoing research using advanced techniques continues to uncover the complexities of human milk's benefits.
  • The composition of human milk transitions over time to meet the evolving needs of the developing infant.