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IL-10 Dysregulation in Acute Mountain Sickness Revealed by Transcriptome Analysis
Bao Liu1,2,3, Jian Chen1,2,3, Long Zhang4
1Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, China.
Frontiers in Immunology
|June 15, 2017
Summary
Acute mountain sickness (AMS) involves immune and inflammatory responses. Researchers found reduced IL10 levels in AMS patients after high-altitude exposure, correlating with symptom severity.
Area of Science:
- Molecular Biology
- Altitude Physiology
- Immunology
Background:
- Acute mountain sickness (AMS) and high-altitude cerebral edema pose significant risks to high-altitude populations.
- Existing research on AMS risk factors and pathophysiology lacks comprehensive molecular mechanism insights.
Purpose of the Study:
- To investigate the molecular mechanisms of AMS using a system-level approach.
- To identify genome-wide transcriptomic changes associated with AMS development.
Main Methods:
- RNA sequencing was employed to analyze gene expression in individuals exposed to high altitude.
- Differential gene expression analysis and network analysis were performed on AMS and non-AMS groups.
- Serum IL10 concentration was measured and correlated with AMS symptoms.
Main Results:
- 1,164 and 1,322 differentially expressed transcripts were identified in AMS and non-AMS groups, respectively.
- Immune and inflammatory responses were significantly overrepresented in the AMS group.
- Downregulation of anti-inflammatory cytokine IL10 and upregulation of IF17F and CCL8 were observed in AMS individuals.
- A significant decrease in serum IL10 concentration post-altitude exposure correlated negatively with AMS severity.
Conclusions:
- High-altitude exposure disturbs genes involved in immune and inflammatory responses in individuals with AMS.
- Reduced IL10 levels after high-altitude exposure are associated with the development of AMS.
