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Effects of Six Kinds of Sodium-Glucose Cotransporter 2 Inhibitors on Metabolic Parameters, and Summarized Effect and

Hidekatsu Yanai1,2, Mariko Hakoshima1, Hiroki Adachi1

  • 1Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.

Journal of Clinical Medicine Research
|June 15, 2017
PubMed
Abstract

Insights

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve glucose control in type 2 diabetes. This study shows SGLT2 inhibitors also benefit weight, blood pressure, liver function, and lipid profiles.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Sodium-glucose cotransporter 2 inhibitors (SGLT2i) promote glucose excretion, improving glycemic control in type 2 diabetes without insulin.
  • The anti-atherosclerotic effects of SGLT2 inhibitors are not fully understood.

Purpose of the Study:

  • To investigate the effects of SGLT2 inhibitors on metabolic parameters and coronary risk factors in patients with type 2 diabetes.

Main Methods:

  • Retrospective chart analysis of type 2 diabetes patients treated with SGLT2 inhibitors for at least 3 months.
  • Comparison of metabolic parameters and coronary risk factors before and 3-6 months after SGLT2 inhibitor initiation.

Main Results:

  • All studied SGLT2 inhibitors (tofogliflozin, canagliflozin, empagliflozin, ipragliflozin, dapagliflozin, luseogliflozin) reduced body weight, blood pressure, glucose, HbA1c, liver enzymes, uric acid, triglycerides, and non-HDL-C.
  • HDL-C levels were elevated by SGLT2 inhibitors.
  • LDL-cholesterol levels remained unaffected.

Conclusions:

  • SGLT2 inhibitors improve glucose metabolism, body weight, blood pressure, liver function, serum lipids, and uric acid in type 2 diabetes patients.
  • These findings suggest broader benefits of SGLT2 inhibitors beyond glycemic control.
Keywords:
Body weightHemoglobin A1cSerum lipidsSodium-glucose cotransporter 2 inhibitorUric acid

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