Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

Inflammation

Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neutrophil killing of Peptoanaerobacter stomatis requires TAK1-driven degranulation.

Journal of innate immunity·2026

Same author

Cystic Fibrosis-Asthma Overlap Syndrome: Current Understanding and Future Directions.

Pediatric pulmonology·2026

Same author

Tyrosine phosphorylation coupling of one-carbon metabolism and virulence in an endogenous pathogen.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Mast Cells Are Intrinsically Primed for Degranulation in DOCK8 Deficiency.

Allergy·2025

Same author

Yersinia pestis Actively Inhibits the Production of Extracellular Vesicles by Human Neutrophils.

Journal of extracellular vesicles·2025

Same author

Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Feb 28, 2026

Intravital Imaging of Neutrophil Priming Using IL-1β Promoter-driven DsRed Reporter Mice

Intravital Imaging of Neutrophil Priming Using IL-1β Promoter-driven DsRed Reporter Mice

Published on: June 22, 2016

Multiple Phenotypic Changes Define Neutrophil Priming.

Irina Miralda¹, Silvia M Uriarte^1,2, Kenneth R McLeish^2,3

¹Department of Microbiology, University of Louisville School of MedicineLouisville, KY, United States.

Frontiers in Cellular and Infection Microbiology

|June 15, 2017

Summary

This summary is machine-generated.

Neutrophil priming involves enhanced responses and activated functions beyond reactive oxygen species (ROS) generation. This state significantly impacts innate and adaptive immunity, suggesting a broader definition is needed.

Keywords:

apoptosis chemotaxis cytokines exocytosis neutrophils phagocytosis priming respiratory burst

More Related Videos

Author Spotlight: Balancing Speed, Cost, and Accuracy in Neutrophil Function Assessment with NeutroFun Screen Protocol

Author Spotlight: Balancing Speed, Cost, and Accuracy in Neutrophil Function Assessment with NeutroFun Screen Protocol

Published on: February 9, 2024

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

Published on: January 3, 2025

Related Experiment Videos

Last Updated: Feb 28, 2026

Intravital Imaging of Neutrophil Priming Using IL-1β Promoter-driven DsRed Reporter Mice

Intravital Imaging of Neutrophil Priming Using IL-1β Promoter-driven DsRed Reporter Mice

Published on: June 22, 2016

Author Spotlight: Balancing Speed, Cost, and Accuracy in Neutrophil Function Assessment with NeutroFun Screen Protocol

Author Spotlight: Balancing Speed, Cost, and Accuracy in Neutrophil Function Assessment with NeutroFun Screen Protocol

Published on: February 9, 2024

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

Published on: January 3, 2025

Area of Science:

Immunology
Cellular Biology
Molecular Mechanisms

Background:

Neutrophils transition from a basal to a primed state upon exposure to various immune stimuli.
Priming is traditionally defined by enhanced reactive oxygen species (ROS) generation via NADPH oxidase.

Purpose of the Study:

To review the diverse phenotypic changes associated with neutrophil priming.
To explore the molecular mechanisms underlying these changes.
To propose a revised, broader definition of neutrophil priming.

Main Methods:

Literature review of studies on neutrophil priming.
Analysis of phenotypic and functional alterations in primed neutrophils.
Examination of molecular pathways involved in neutrophil priming.

Main Results:

Primed neutrophils exhibit enhanced responsiveness in exocytosis, NET formation, and chemotaxis.
Phenotypic changes include activated adhesion, transcription, metabolism, and apoptosis.
Molecular mechanisms driving these diverse changes are actively being elucidated.

Conclusions:

The current definition of neutrophil priming is too restrictive.
Priming encompasses both enhanced responsiveness and activated functions.
This broader understanding is crucial for regulating innate and adaptive immune responses.