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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty

Qiangqiang Li1,2, Bingyang Dai2,3, Yao Yao2,3

  • 1Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.

Biomed Research International
|June 15, 2017
PubMed

Insights

Chronic kidney dysfunction (CKD) significantly increases the risk of deep vein thrombosis (DVT) after total joint arthroplasty (TJA). This highlights the need for prioritized DVT prophylaxis in CKD patients undergoing TJA.

Area of Science:

  • Orthopedic Surgery
  • Nephrology
  • Vascular Medicine

Background:

  • Deep vein thrombosis (DVT) is a significant complication following total joint arthroplasty (TJA).
  • Chronic kidney dysfunction (CKD) is common in TJA patients and creates a prothrombotic state.
  • The relationship between CKD and DVT risk post-TJA requires further investigation.

Purpose of the Study:

  • To determine if chronic kidney dysfunction (CKD) elevates the risk of deep vein thrombosis (DVT) after total joint arthroplasty (TJA).

Main Methods:

  • A retrospective analysis of 1274 patients undergoing primary TJA.
  • CKD was categorized into 5 stages.
  • Univariate and multivariate analyses assessed the association between CKD severity and postoperative DVT.

Main Results:

  • Of 1274 patients, 19.2% developed DVT, and 5.0% had symptomatic DVT.
  • Advanced age, female gender, malignancy, and lower estimated glomerular filtration rate (eGFR) were linked to total DVT.
  • Lower eGFR was independently associated with both total and symptomatic DVT after adjusting for other factors.

Conclusions:

  • Chronic kidney dysfunction (CKD) is a significant risk factor for DVT after TJA.
  • Both total and symptomatic DVT are more prevalent in patients with CKD.
  • Enhanced DVT prophylaxis is crucial for CKD patients undergoing TJA.
Abstract

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