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Related Experiment Videos

Neuroleptic bioequivalency: tablet versus concentrate.

W E Fann, A F Moreira

    Journal of Clinical Pharmacology
    |May 1, 1985
    PubMed
    Summary
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    This study compared two forms of the antipsychotic molindone (tablet and liquid concentrate) in psychotic patients. Results show both oral molindone forms are equally bioavailable, offering equivalent therapeutic potential.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Clinical Pharmacy

    Background:

    • Molindone is an antipsychotic neuroleptic used in treating psychosis.
    • Understanding the bioavailability of different drug formulations is crucial for effective patient treatment.
    • Previous research has not definitively established the comparative bioavailability of molindone tablet versus liquid concentrate forms.

    Purpose of the Study:

    • To compare the clinical bioavailability of two oral forms of molindone: a coated tablet and a liquid concentrate.
    • To determine if equivalent doses of molindone administered via tablet or liquid concentrate result in similar systemic absorption in patients with psychosis.

    Main Methods:

    • A crossover study design was employed with newly admitted psychotic patients.
    • Patients received molindone coated tablet for ten days, followed by molindone liquid concentrate for four days, with equivalent doses administered.

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  • Plasma concentrations of the parent molindone compound were analyzed using gas chromatography with electron capture detection after each dosing phase.

    • Main Results:

    • Gas chromatography analysis revealed comparable plasma levels of molindone following administration of both the tablet and liquid concentrate forms.
    • The data indicate that the absorption of molindone from the gastrointestinal tract is similar for both tested formulations.
    • No significant differences in bioavailability were observed between the molindone tablet and liquid concentrate.

    Conclusions:

    • Oral administration of both coated tablet and liquid concentrate forms of molindone results in equivalent clinical bioavailability.
    • The findings suggest that either formulation can be used interchangeably, providing similar therapeutic efficacy in patients with psychosis.
    • This equivalence simplifies treatment selection and dosing for molindone in clinical practice.