[Fosfomycin, an old antibiotic with new possibilities].

Area of Science:

• Pharmacology
• Infectious Diseases
• Microbiology

Background:

• Fosfomycin is a broad-spectrum antibiotic, commonly used orally for uncomplicated cystitis.
• Intravenous fosfomycin has recently been approved in the Netherlands.
• Its broad spectrum and tissue penetration suggest potential for treating various organ infections.

Purpose of the Study:

• To explore the potential of fosfomycin in treating infections caused by multidrug-resistant bacteria.
• To highlight the need for further research into fosfomycin's pharmacological properties and safety profile.

Main Methods:

• Literature review on fosfomycin's properties and applications.
• Analysis of fosfomycin's spectrum of activity against resistant pathogens.
• Assessment of existing knowledge gaps regarding dosing, safety, and tolerability.

Main Results:

• Fosfomycin demonstrates sensitivity against many multidrug-resistant bacteria.
• The drug's pharmacokinetic properties require further investigation for optimal dosing strategies.
• Limited data exists on fosfomycin's safety and tolerability in diverse infection types.

Conclusions:

• Fosfomycin presents a potential therapeutic option for multidrug-resistant bacterial infections.
• Comprehensive research is essential to establish robust dosing regimens and confirm safety before widespread use.
• Further studies are required to fully leverage fosfomycin in combating antimicrobial resistance.