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Recording nerve signals in canine sciatic nerves with a flexible penetrating microelectrode array
Donghak Byun1, Sung-Joon Cho2, Byeong Han Lee3
1School of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.
Journal of Neural Engineering
|June 15, 2017
Summary
This study shows a flexible penetrating microelectrode array (FPMA) effectively records from peripheral nerves in animals. The device demonstrates viability for chronic neural interfacing, paving the way for human applications.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Materials Science
Background:
- Flexible penetrating microelectrode arrays (FPMAs) were previously fabricated for neural interfacing.
- The need for chronic intrafascicular recording tools for peripheral nerve applications is growing.
Purpose of the Study:
- To demonstrate the feasibility of the developed FPMA as a chronic intrafascicular recording tool for peripheral nerves.
- To evaluate the FPMA's performance and safety in medium-sized animal models.
Main Methods:
- FPMA integrated with custom components for canine sciatic nerves.
- Characterization of electrode uniformity and in vitro electrochemical properties.
- In vivo electrophysiological recordings (acute and chronic for 4 weeks) in canine sciatic nerves.
- Histological examination of implanted nerve tissues.
Main Results:
- Successful multi-channel recordings of nerve spikes achieved (up to 73% viable channels).
- High signal quality (SNR > 4.9) for recorded neural signals.
- Minimal observed damage to nerve tissue morphology post-implantation.
Conclusions:
- The FPMA is viable for chronic peripheral nerve recording in medium-sized animals.
- Results support further development towards bidirectional neural interfaces for human use.
- The study advances the potential for clinical translation of neural interface technology.
