T₁-T₂ Dual-Modal Magnetic Resonance Imaging: From Molecular Basis to Contrast Agents

Multimodal imaging strategies integrating manifold images have improved our ability to diagnose, to guide therapy, and to predict outcomes. Magnetic resonance imaging (MRI) is among the most widely used imaging technique in the clinic and can enable multiparameter anatomical demonstration of diagnosis. Due to the inherent black-and-white production of MR images, however, MRI detection is largely hampered by the occurrence of false-positive diagnoses. In this Perspective, we introduce the paradigm of manipulating the multiparameter MRI, T₁-T₂ dual-modal MRI, along with enhancement by specific contrast agents. We hope this discussion will promote emerging research interest in T₁-T₂ dual-modal MRI and provoke the rational design of contrast agents for sophisticated MRI applications.