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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Two Cases of Sinusitis Induced by Immune Checkpoint Inhibition
Eric Dein1, William Sharfman, Jean Kim
1Departments of *Medicine, Division of Rheumatology †Oncology ‡Otolaryngology §Radiology, Johns Hopkins School of Medicine, Baltimore, MD.
Abstract:
We report the acute onset of aseptic sinusitis in 2 patients receiving the immune checkpoint inhibitors, ipilimumab and nivolumab, for treatment of metastatic melanoma. Ipilimumab, a monoclonal antibody targeting cytotoxic T-lymphocyte antigen-4, and nivolumab, targeting programmed cell death-1, have been associated with numerous immune-related adverse events. To the authors' knowledge, this is the first report of aseptic sinusitis as a consequence of immune checkpoint inhibition therapy.

