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Ibuprofen exposure in early neonatal life does not affect renal function in young adolescence

Anke Raaijmakers1,2, Zhen-Yu Zhang1,2,3, Elena Levtchenko1

  • 1Department of Pediatrics and Neonatology, University Hospitals Leuven, Leuven, Belgium.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|June 16, 2017
PubMed

Insights

Neonatal ibuprofen exposure did not impact long-term kidney function in extremely low birth weight infants. Further research is needed to understand variability in renal outcomes for these high-risk children.

Area of Science:

  • Neonatal medicine
  • Pediatric nephrology
  • Pharmacology

Background:

  • Ibuprofen can cause temporary kidney problems in newborns.
  • Long-term kidney safety data after neonatal ibuprofen exposure is limited.
  • Extreme low birth weight (ELBW) infants are at higher risk for later-life cardiovascular and renal disease.

Purpose of the Study:

  • To assess the long-term renal safety of neonatal ibuprofen exposure.
  • To investigate the association between ibuprofen exposure and renal function markers at age 11 in ELBW infants.
  • To identify perinatal risk factors for long-term renal outcomes in ELBW survivors.

Main Methods:

  • Post hoc analysis of the PREMATurity study cohort (93 ELBW infants).
  • Assessed renal length and estimated glomerular filtration rate (eGFRcysC) at age 11.
  • Linked renal function data with perinatal characteristics, including neonatal ibuprofen exposure.

Main Results:

  • No significant difference in renal length or eGFRcysC was found between ibuprofen-exposed and unexposed ELBW infants.
  • No other identified perinatal factors were associated with long-term renal outcomes.
  • The study did not find evidence of long-term renal impairment due to neonatal ibuprofen exposure.

Conclusions:

  • Neonatal ibuprofen exposure does not appear to affect long-term renal function in ELBW survivors.
  • Further investigation is required to understand factors influencing renal function variability in this population.
  • Identifying risk factors is crucial for potential secondary prevention strategies in ELBW individuals.
Abstract

Keywords:
Cystatin Cdrug safetyibuprofenpreterm

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