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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

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Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Members Made of Elastoplastic Material01:19

Members Made of Elastoplastic Material

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The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Related Experiment Video

Updated: Feb 28, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
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Periumbilical pseudoxanthoma elasticum.

V Vishalakshi1, R G Torsekar1

  • 1Department of Dermatology, CSM Hospital & Rajiv Gandhi Medical College, Kalwa, Thane, Maharashtra, India.

Indian Journal of Dermatology, Venereology and Leprology
|June 16, 2017
PubMed
Summary

Pseudoxanthoma elasticum (PXE) typically affects skin, eyes, and blood vessels. This report details a rare case of localized, PXE-like skin changes in the periumbilical area without systemic involvement.

Area of Science:

  • Dermatology
  • Connective Tissue Diseases
  • Genetics

Background:

  • Pseudoxanthoma elasticum (PXE) is an inherited disorder of connective tissue.
  • PXE commonly affects the skin, eyes, and vascular system.
  • Diagnosis is typically based on clinical presentation and characteristic skin biopsy findings.

Observation:

  • A unique case presented with skin lesions mimicking PXE.
  • The lesions were exclusively located in the periumbilical region.
  • No evidence of ocular or vascular involvement was detected.

Findings:

  • The case highlights localized, PXE-like cutaneous manifestations.
  • Differential diagnoses for such localized changes include perforating calcific elastosis and papillary dermal elastolysis.

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  • Histopathological examination is crucial for differentiating these conditions.

    • Implications:

    • This case expands the clinical spectrum of PXE presentations.
    • It underscores the importance of considering localized elastotic disorders.
    • Further research may elucidate the specific genetic or environmental factors contributing to localized PXE-like conditions.