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Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression
Hae-Young Lopilly Park1, Jiyoung Lee1, Younhea Jung1
1Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Scientific Reports
|June 16, 2017
Summary
Glaucoma progression is linked to disc hemorrhages (DH) and lamina cribrosa (LC) defects. Eyes with both DH and LC defects show faster visual field progression, highlighting LC evaluation
Area of Science:
- Ophthalmology
- Glaucoma Research
- Optic Nerve Head Imaging
Background:
- Disc hemorrhages (DH) and focal lamina cribrosa (LC) defects are emerging as glaucoma progression factors.
- The clinical significance of concurrent DH and LC defects remains unclear.
Purpose of the Study:
- To investigate if visual field (VF) progression in glaucoma differs based on LC findings at the DH site.
- To determine the relationship between LC defects, DH, and glaucoma progression using optical coherence tomography (OCT).
Main Methods:
- Prospective study of 98 glaucoma eyes with DH and 37 OAG eyes with LC defects without DH.
- Enhanced depth imaging (EDI) of OCT used to evaluate LC findings.
- Analysis of VF progression in relation to DH and LC defect presence and location.
Main Results:
- Focal LC defects were significantly associated with VF progression (P < 0.001).
- Presence of focal LC defects at the DH site was a significant predictor of VF progression (HR, 2.620; P = 0.002).
- Glaucoma eyes with DH and concurrent LC defects exhibited more frequent and faster VF progression.
Conclusions:
- Evaluating LC alterations in glaucoma eyes with DH is crucial for predicting disease progression.
- Concurrent DH and LC defects indicate a higher risk of rapid visual field loss in glaucoma patients.
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