Intensive blood pressure control in patients with acute type B aortic dissection (RAID): study protocol for...

Area of Science:

• Cardiovascular Medicine
• Vascular Surgery
• Critical Care

Background:

• Blood pressure control is crucial for acute type B aortic dissection (ABAD).
• Current guidelines recommend a target below 140/90 mmHg, but optimal levels remain debated.
• Lowering blood pressure may reduce dissection propagation but risks compromising organ perfusion.

Purpose of the Study:

• To determine the optimal blood pressure target for patients with ABAD.
• To investigate whether intensive blood pressure control (<120 mmHg) is superior to conventional control (<140 mmHg).

Main Methods:

• Multi-center randomized controlled trial involving 360 patients with new-onset ABAD and hypertension.
• Randomization to intensive (<120 mmHg) or conventional (<140 mmHg) blood pressure control.
• Primary outcome: composite in-hospital adverse events (death, paralysis, renal failure).

Main Results:

• Interim analysis will be performed.
• Secondary outcomes include aortic size, ischemia, mortality, and intervention rates.

Conclusions:

• The study aims to optimize treatment strategies for aortic dissection.
• Results will inform clinical guidelines on blood pressure management in ABAD.