Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.9K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.9K
Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

923
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
923
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

5.6K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
5.6K
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

669
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
669

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase 2b trial of inhaled imatinib for treatment of pulmonary arterial hypertension.

American journal of respiratory and critical care medicine·2026
Same author

IMPAHCT: A randomized phase 2b/3 study of inhaled imatinib for pulmonary arterial hypertension.

Pulmonary circulation·2024
Same author

AV-101, a novel inhaled dry-powder formulation of imatinib, in healthy adult participants: a phase 1 single and multiple ascending dose study.

ERJ open research·2023
Same author

Erratum: Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: An analysis of the Pulmonary Hypertension Association Registry.

Pulmonary circulation·2022
Same author

INSPIRE: Safety and tolerability of inhaled Yutrepia (treprostinil) in pulmonary arterial hypertension (PAH).

Pulmonary circulation·2022
Same author

Health-related quality of life and hospitalizations in chronic thromboembolic pulmonary hypertension versus idiopathic pulmonary arterial hypertension: an analysis from the Pulmonary Hypertension Association Registry (PHAR).

Pulmonary circulation·2021
Same journal

Xanthomatous pleuritis in a child with recurrent pneumonia and patent ductus arteriosus: A rare pediatric case report and literature review.

Respiratory medicine case reports·2026
Same journal

Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy.

Respiratory medicine case reports·2026
Same journal

Bronchial Dieulafoy disease: A case report and literature review.

Respiratory medicine case reports·2026
Same journal

Unilateral diffuse alveolar haemorrhage as an atypical presentation of PR3-ANCA-associated vasculitis: A case report.

Respiratory medicine case reports·2026
Same journal

Subcutaneous apomorphine-induced pneumonitis: An uncommon pulmonary adverse event.

Respiratory medicine case reports·2026
Same journal

Internal auditory canal metastasis as the only brain lesion in progressive lung adenocarcinoma: Case report and literature review.

Respiratory medicine case reports·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.4K

Blue after splenectomy.

Taaran Cariappa Ballachanda Subbaiah1, Jeremy P Feldman2

  • 1St. Joseph's Hospital and Medical Center, USA.

Respiratory Medicine Case Reports
|June 16, 2017
PubMed
Summary
This summary is machine-generated.

Splenectomy may increase the risk of developing methemoglobinemia in patients taking dapsone. This case highlights the interaction between dapsone, splenic function, and methemoglobin levels, suggesting a novel risk factor for this adverse drug reaction.

Keywords:
DapsoneHypoxemiaMethemoglobinemiaSolid organ transplantSplenectomy

More Related Videos

Application of Microwave Ablation in Laparoscopic Partial Splenectomy
03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

Published on: November 15, 2024

593
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

885

Related Experiment Videos

Last Updated: Feb 28, 2026

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.4K
Application of Microwave Ablation in Laparoscopic Partial Splenectomy
03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

Published on: November 15, 2024

593
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

885

Area of Science:

  • Pharmacology
  • Hematology
  • Immunology

Background:

  • Dapsone is a commonly used medication for prophylaxis against Pneumocystis Jiroveci pneumonia.
  • Methemoglobinemia is a known adverse effect of dapsone, but its occurrence can be influenced by various factors.
  • Splenic function plays a role in erythrocyte turnover and may influence drug-induced toxicity.

Observation:

  • A 51-year-old female on long-term dapsone therapy developed persistent hypoxemia after a splenectomy.
  • Despite years of dapsone use without prior issues, the patient presented with a significant methemoglobin (MHb) level of 16.6 mg/dl post-splenectomy.
  • The patient had a history of type 1 diabetes, multiple pancreas transplants, a kidney transplant, and a distal pancreatectomy with incidental splenectomy.

Findings:

  • The case suggests a potential interaction between dapsone and splenectomy, increasing the risk of methemoglobinemia.
  • It is hypothesized that the spleen normally removes older, more susceptible erythrocytes, but post-splenectomy, an increase in older erythrocytes leads to MHb accumulation.
  • Discontinuation of dapsone and administration of vitamin C resulted in the resolution of methemoglobinemia and normalization of oxygen saturation.

Implications:

  • This case highlights a previously undocumented relationship between dapsone, splenic function, and methemoglobinemia.
  • Clinicians should consider the impact of splenectomy on dapsone-induced methemoglobinemia risk, especially in patients with prolonged dapsone use.
  • Further research is warranted to elucidate the mechanisms underlying this interaction and to inform clinical management strategies.