Related Experiment Video
Updated: Feb 28, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Drug Reaction with Eosinophilia and Systemic Symptom in a Patient with Pneumonia and Hyperthyroidism
Hualiang Jin1, Limin Wang1, Jian Ye1
1Department of Respiratory Diseases, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang, China.
Abstract:
Drug rash with eosinophilia and systemic symptoms syndrome is an idiosyncratic drug reaction characterized by fever, skin eruption, lymph node enlargement, and internal organ involvement. We report a case of a patient with pneumonia who developed clinical manifestations of fever, rash, lymphadenopathy, hypereosinophilia, and visceral involvement (renal failure and eosinophilic pneumonitis) caused by methimazole. The patient improved remarkably with drug withdrawal. A high index of clinical suspicion is emphasized to facilitate prompt diagnosis of medication-related adverse effect and its discontinuation.
Related Concept Videos
Allergic Reactions
Drug Toxicity: Allergic Reactions
Allergic Reactions: Anaphylaxis
Hypersensitivity Reactions: Cytolytic Reactions
Allergic Drug Reactions
Hypersensitivity Reactions: Immune-Complex Reactions

