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Metallic ion release after knee prosthesis implantation: a prospective study
Adrien Lons1,2, Sophie Putman1,2, Gilles Pasquier1,2
1Université de Lille Nord de France, F-59000, Lille, France.
International Orthopaedics
|June 16, 2017
Summary
Knee replacement surgery significantly increases blood levels of chromium, cobalt, and titanium one year post-implantation. This metallic ion release may cause adverse health effects like allergies and hypersensitivity.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Toxicology
Background:
- Metal-on-metal hip implants release ions, causing health issues.
- Limited data exists on ion levels following knee arthroplasty.
- This study investigates metallic ion release after knee replacement.
Purpose of the Study:
- To determine if knee arthroplasty elevates blood levels of chromium (Cr), cobalt (Co), and titanium (Ti).
- To assess metallic ion levels during the first year after knee replacement surgery.
Main Methods:
- Prospective study of patients undergoing knee arthroplasty.
- Measured Cr, Co, and Ti levels in whole blood pre-operation and at 1-year follow-up.
- Collected clinical and radiographic data, including range of motion and patient-reported scores (Oxford, IKS).
Main Results:
- Blood levels of Cr, Co, and Ti significantly increased one year post-surgery (p < 0.0001).
- Preoperative levels (0.45, 0.22, 2.94 μg/l) rose to 1.27, 1.41, 4.08 μg/l respectively.
- Mean Oxford and IKS scores improved significantly (p < 0.001).
Conclusions:
- Knee arthroplasty leads to significant elevation of blood Cr, Co, and Ti levels one year post-implantation.
- These elevated metallic ion levels exceed normal values.
- Potential health implications include allergy and hypersensitivity reactions.
